Roger D Cone Selected Research

Therapeutics

12/2023	Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents.
1/2021	The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia.
6/2012	Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.

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Roger D Cone Research Topics

Disease

28	Obesity 12/2023 - 07/2002
9	Cachexia 02/2024 - 04/2003
9	Body Weight (Weight, Body) 12/2023 - 05/2003
9	Hyperphagia (Overeating) 01/2021 - 06/2003
6	Weight Loss (Weight Reduction) 12/2023 - 04/2003
5	Anorexia 01/2021 - 07/2002
4	Hypertension (High Blood Pressure) 01/2017 - 04/2003
4	AIDS-Related Complex (ARC) 07/2006 - 06/2003
4	Weight Gain 06/2005 - 07/2003
3	Hypertrophy 01/2021 - 03/2006
2	Neoplasms (Cancer) 02/2024 - 04/2003
2	Anorexia Nervosa 01/2023 - 01/2019
2	Insulin Resistance 03/2016 - 12/2007
2	Inflammation (Inflammations) 06/2012 - 12/2007
2	Malnutrition (Nutritional Deficiencies) 09/2006 - 03/2005
2	Uremia 09/2006 - 06/2005
1	Psychological Sexual Dysfunctions (Sexual Arousal Disorder) 01/2023
1	Erythropoietic Protoporphyria 01/2023
1	Phototoxic Dermatitis (Phototoxicity) 01/2023
1	Glucose Intolerance 01/2019
1	Mental Disorders (Mental Disorder) 01/2019
1	Blindness (Hysterical Blindness) 11/2018
1	Epilepsy (Aura) 01/2018
1	Renal Insufficiency (Renal Failure) 01/2018
1	Retinal Degeneration 01/2018
1	Diabetes Mellitus 01/2018
1	Cardiac Arrhythmias (Arrythmia) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2017
1	Bradycardia 01/2017
1	Hyperplasia 03/2016
1	Infertility (Sterility) 03/2016
1	Morbid Obesity 06/2012
1	Fatty Liver 12/2007
1	Chronic Kidney Failure (Chronic Renal Failure) 09/2006
1	Chronic Renal Insufficiency 03/2005
1	Thinness 04/2004

Drug/Important Bio-Agent (IBA)

20	MelanocortinsIBA 01/2023 - 07/2002
18	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 02/2024 - 04/2003
10	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 12/2023 - 04/2003
10	LeptinIBA 01/2022 - 11/2003
8	Peptides (Polypeptides)IBA 12/2023 - 06/2003
5	Type 3 Melanocortin ReceptorIBA 01/2021 - 04/2003
4	setmelanotideIBA 12/2023 - 04/2015
4	CytokinesIBA 09/2006 - 04/2003
3	Melanocortin Receptors (Melanocortin Receptor)IBA 01/2023 - 04/2003
3	Agouti-Related ProteinIBA 01/2021 - 01/2004
2	Appetite Depressants (Anorectics)IBA 12/2023 - 06/2003
2	Leptin ReceptorsIBA 12/2023 - 03/2016
2	AdipokinesIBA 01/2022 - 09/2006
2	LipidsIBA 01/2019 - 03/2011
2	SaltsIBA 06/2012 - 04/2003
2	gamma-MSHIBA 11/2006 - 04/2003
2	alpha-MSHIBA 11/2006 - 04/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2006 - 03/2005
2	Hormones (Hormone)IBA 09/2006 - 07/2006
2	Blood Proteins (Serum Proteins)IBA 09/2006 - 03/2005
2	GhrelinIBA 09/2006 - 07/2006
2	CorticosteroneIBA 11/2003 - 04/2003
1	IncretinsIBA 12/2023
1	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2023
1	Polylactic Acid-Polyglycolic Acid CopolymerIBA 12/2023
1	bremelanotideIBA 01/2023
1	afamelanotideIBA 01/2023
1	tubastatin AIBA 01/2022
1	Histone Deacetylase 6IBA 01/2022
1	ArrestinIBA 10/2019
1	PotassiumIBA 01/2019
1	Ion Channels (Ion Channel)IBA 01/2019
1	GTP-Binding Proteins (G-Protein)IBA 01/2019
1	Retinaldehyde (Retinal)IBA 11/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2018
1	ElectrolytesIBA 01/2018
1	CarbohydratesIBA 04/2013
1	AutoreceptorsIBA 06/2011
1	Dietary Fats (Dietary Fat)IBA 03/2011
1	N-acylphosphatidylethanolamineIBA 03/2011
1	Interleukin-6 (Interleukin 6)IBA 09/2006
1	AdiponectinIBA 09/2006
1	ResistinIBA 09/2006
1	Interleukin-1 (Interleukin 1)IBA 09/2006
1	Amphetamine (Amfetamine)FDA LinkGeneric 07/2006
1	Cocaine (Cocaine HCl)IBA 07/2006
1	4-Nle-7-Phe-alpha- MSHIBA 03/2006
1	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2005
1	Ubiquitin CIBA 06/2005
1	NeuropeptidesIBA 03/2005
1	InterleukinsIBA 03/2005
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 01/2004
1	CeruleninIBA 01/2004
1	Pheromones (Semiochemicals)IBA 11/2003
1	Testosterone (Sustanon)FDA Link 11/2003
1	Insulin (Novolin)FDA Link 11/2003
1	Hydrocortisone (Cortisol)FDA LinkGeneric 11/2003
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 07/2003
1	trkB ReceptorIBA 07/2003

Therapy/Procedure

3	Therapeutics 12/2023 - 06/2012
2	Injections 12/2023 - 11/2006
1	Microspheres (Microsphere) 12/2023
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 06/2012